Slayton's research and teaching examine the relationships between and among risk, governance, and expertise, with a focus on international security and cooperation since World War II. Her first book, Arguments that Count: Physics, Computing, and Missile Defense, 1949-2012 (MIT Press, 2013), shows how the rise of a new field of expertise in computing reshaped public policies and perceptions about the risks of missile defense in the United States. In 2015, Arguments that Count won the Computer History Museum Prize.